Cell cycle control and cancer chemotherapy
نویسندگان
چکیده
منابع مشابه
Optimal Control Applied to Cell-Cycle-Specific Cancer Chemotherapy
In this paper, the optimal drug injection problem arising in cancer treatment by cell-cycle-specific chemotherapy is investigated. The optimal control problem is state constrained in which the stage cost reflects the concern of maximal drug injection, while the state constraint imposes a lower bound on the total number of cells in the bone marrow. It is shown that this problem can be approximat...
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Cancer is a multifaceted disease, but a common feature of most tumours is that they harbour one or more genetic mutations that allow them to proliferate outside their normal growth restraints. Proliferation is normally restrained through control of the cell division cycle, which in turn, is regulated by the Cdk family of serine/threonine kinases and their regulatory partners the cyclins. Here, ...
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Cell-cycle specific chemotherapy is a common procedure for treating cancer, administered by using drugs that attack cells in particular phases of the cell-cycle. The phases of the cell-cycle that are relevant for chemotherapy differ for each drug, for instance, Cyclophosphamide acts on cells in the DNA replication phase, while Taxol targets cells in the division phase (Fister et. al., 2000). Th...
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Cancer is frequently considered to be a disease of the cell cycle. As such, it is not surprising that the deregulation of the cell cycle is one of the most frequent alterations during tumor development. Cell cycle progression is a highlyordered and tightly-regulated process that involves multiple checkpoints that assess extracellular growth signals, cell size, and DNA integrity. Cyclin-dependen...
متن کاملRole of E2F in cell cycle control and cancer.
E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in progression through G1 and into the S-phase of the cell cycle. The activity of E2F factors is regulated through association with the retinoblastoma tumor suppressor protein (Rb) and the other pocket proteins, p107 and p130. Binding of Rb, p107 or p130 converts E...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 1994
ISSN: 0730-2312,1097-4644
DOI: 10.1002/jcb.240540411